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300 In the parental ID8 murine ovarian cancer model harbouring a knock-out of p53 (ID8p53) and MISIIR-Tag spontaneous ovarian cancer models, CGX-1321(Wnt inhibitor) increased infiltrating CD8 + T cells in the TME and decreased tumour burden

[ref] Not only is B6 important in dopamine production, but it is also important in the creation of glutathione (an antioxidant) in the brain.[ref] Parkinsons patients on L-DOPA also often have low or deficient B6 levels.[ref] Related article : Parkinsons disease and genetic susceptibility Chronic inflammation: Inflammatory conditions, including rheumatoid arthritis, IBD, diabetes, cancer, and deep vein thrombosis, are all associated with low vitamin B6 levels.[ref] While inflammatory conditions are linked to low vitamin B6 levels, it may be (at least partly) because systemic inflammation decreases the bodys P5P levels, and dietary intake isnt sufficient to meet the increased need.[ref] Related article: Chronic inflammation and personalized solutions Asthma and COPD: A recent study showed that higher vitamin B6 intake correlates with higher FEV1 levels (lung function test) in CoPD

Nat Rev Drug Discov 8(7):579591

This can lead to decreased membrane deformability

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